Otrexyo is a registered trademark of Pfizer. AMRN closed Friday's trading at $24.12, up 4.92%. Calyxt, Inc. (Nasdaq: CLXT), a plant-based synthetic biology company, and Cibus, a leader in precision gene editing in agriculture, today announced that both companies have entered into a definitive merger agreement under which Calyxt and Cibus will merge in an all-stock transaction. Biotech companies have had an easy time raising huge sums of money from private investors and, until recently, the public markets. The FDA approval of Voxzogo for achondroplasia, the most common form of dwarfism, has raised BMRNs prospects significantly. Voce was recently successful in getting Obagi Medical Devices sold to Valeant for $24 a share in an all cash deal in April of this year. Even with a market cap of over $2B, we feel Acadia could fetch as much as $6B if the FDA approves pimavanserin, which could happen in the next 6 to 8 months. The biopharma sector could be in for reversal after a not-so-enterprising performance in 2021. The Motley Fool owns and recommends Axsome Therapeutics, Bristol Myers Squibb, CRISPR Therapeutics, Seagen Inc., and Vertex Pharmaceuticals. In 2003, Alnylam merged with the German pharmaceutical company, Ribopharma AG. Alnylam stock has a market capitalization of over $20 billion. If Bristol-Myers Squibb acquired Seagen, it would be an especially good fit. *Average returns of all recommendations since inception. As well Dan has 5 years trading futures, specializing in E-minis and Treasury products. Sold Tercica to Ipsen: Mr. King served as President and General Manager of Tercica. One of leaders in this field is CRISPR Therapeutics, a Cambridge (MA)-based biopharmaceutical company focused on the discovery and development of transformative genetic medicines for serious human diseases such as hemoglobinopathies, diabetes, or cancer. Places you can follow Scott are: www.stockmatusow.com www.twitter.com/StockMatusow @StockMatusow http://www.facebook.com/TheScottMatusowShow Places to follow Dan are: https://twitter.com/biosleuth. The most recent update provided by the company suggests it may take several quarters for the issue to be resolved. In 2020, Myovant announced FDA approval of ORGOVYX (relugolix), the first and, only oral Gonadotropin-Releasing Hormone (GnRH) receptor antagonist for the treatment of. Brian Orelli: I'd like to see Bristol-Myers Squibb (BMY -0.28%) acquire Seagen (SGEN -1.71%). These symbols will be available throughout the site during your session. Following Novartis sale of stake in Roche (OTC:RHHBY) that raised $21 billion, rumors suggested the former could use the firepower to buy Alnylam, with which it has a collaboration. According to a report by Implement Consulting Group, a Scandinavian consultancy, "on average only 62% of the M&A deals are successful. CRISPRs lead product candidate, CTX001, is an investigational, autologous, gene-edited hematopoietic stem cell therapy that is being evaluated for the treatment of transfusion-dependent beta thalassemia (TDT) and severe sickle cell disease (SCD). The first few months lived up to expectations: All of the top 10 M&A deals of January-June 2018 exceeded $1.5 billion, paced by the completion of Bayer's $63 billion buyout of Monsanto . Outsmart the market with Smart Portfolio analytical tools powered by TipRanks. I think those could be intriguing deals for the new year. Here's the Stock to Buy Now, Join Nearly 1 Million Premium Members And Get More In-Depth Stock Guidance and Research, Motley Fool Issues Rare All In Buy Alert, Copyright, Trademark and Patent Information. Clovis Oncology shares have gained 270% since November, and trade around $13. PwC also expects large-sized deals, valued at $50 billion or more, for diversifying into adjacent therapeutic areas. Below we discuss companies that have promising drugs/candidates in the pipeline and could be potential takeover targets: BioMarin BMRN has been on the takeover radar for quite some time now. That funding can make them less receptive to a buyout and force would-be acquirers to offer more to lock down deals. And there are often rumors of other deals that never materialize. Learn More. Biotech companies have had an easy time raising huge sums of money from private investors and, until recently, the public markets. There's a company called Adicet Bio (ACET 0.46%), ticker there is ACET, I believe. If you have an ad-blocker enabled you may be blocked from proceeding. Are you interested in learning more about small- and mid-cap biotech stocks with exceptional growth potential and some of the hottest takeover targets of the industry? Here's a look at the 10 top takeover targets. The results of one of biotech's most polarizing clinical trials, an Alnylam Pharmaceuticals study in a rare disease known as transthyretin amyloidosis cardiomyopathy, are expected imminently. Stay on top of what's happening at JPM. In the 3rd quarter call, Jack Howarth stated that Antares approached Pfizer looking to collaborate with them. 2, I agree with you that the CRISPR gene-editing companies are probably near the top of the list of potential acquisition targets over the next few years. Two exceptions: Amgen's $13.4 billion acquisition of the psoriasis medicine Otezla and Novartis' $3.4 billion acquisition of the dry eye drug Xiidra, which are included for their notable size and importance to the acquirer. Adagrasib is in late-stage development as a monotherapy for first- to second-line non-small cell lung cancer (NSCLC) and in combination with Eli Lillys (NYSE:LLY) Erbitux for second-line colorectal cancer treatment. While M&A was plentiful in 2018 and 2019, and even held up during a year gripped by the coronavirus pandemic, 2021 was much quieter. David Callan was actively involved SRI Surgical (Formerly Nasdaq listed STRC) unsolicited offer bid and eventual sale of the company. Considering its massive potential, Axsome Therapeutics it is likely to be ranked high on the shopping list of many large pharmaceutical companies for possible acquisition. *Stock Advisor returns as of January 10, 2022. 4 Biotechs That Could Be Potential Acquisition Targets in 2021. Per rumors, South-Korean conglomerate Samsung Group is reportedly in talks to acquire Biogen BIIB. Best Penny Stocks . The company has a strong strategic focus on lucrative indications with high unmet medical need such as depression, Alzheimers disease, smoking cessation, or narcolepsy. The company has already seven products on the market. FTX Fooled the World. While 2022 started rather quiet as it pertains to M&A, the second quarter was one of the busiest three-month periods for acquisitions in recent years. In fact, the second quarter hit a five-year low in both the value and number of biopharma transactions. The rumors on Obagi turned out to be correct, as the company was sold last. Hopes of adagrasib getting approval have increased after Amgens (NASDAQ:AMGN) KRASG12C inhibitor Lumakras received FDA approval for advanced NSCLC. Aesther Healthcare Acquisition Corp and Ocean Biomedical, Inc. announced that AEHA has filed with the U.S. Securities and Exchange Commission a definitive proxy statement in connection with its proposed business combination with Ocean and with respect to the special meeting of Aesthers stockholders scheduled to be held on February 3, 2023. Powered by Madgex Job Board Software. Are you interested in learning more about small- and mid-cap biotech stocks with exceptional growth potential and some of the hottest takeover targets of the industry? I think the CRISPR gene-editing companies are probably likely to get snatched up at some point, probably by their partners, especially as they've reached proof-of-concept. Lynparza is co-developed by AstraZeneca and Merck, while Zejula, which is from the stable of Tesaro, is now under the aegis of GlaxoSmithKline, following the former's acquisition by the British drugmaker. We have been hearing some strong acquisition rumors concerning AcelRx, much like we heard about Obagi last year. Cost basis and return based on previous market day close. Dan utilizes his experience reading and reviewing scientific literature to evaluate prospects for success. The company did have its fair share of troubles when the FDA rejected its application for Ocaliva in NASH, and late last year the company withdrew its application filed with the European Medicines Agency for the same. Miratis KRASG12C inhibitor adagrasib is evaluated as a monotherapy and in combination for several cancer indications. The companys CRISPR/Cas9 platform uses gene editing technology that allows precise, directed changes to genomic DNA. The database, which shows drugmaker acquisitions that happened since 2018 and were valued at $50 million or more in upfront consideration, will be regularly updated. Last month, Adaptimmune announced that SPEARHEAD-1 trial evaluating afamitresgene autoleucel (afami-cel, formerly ADP-A2M4) in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) will meet its primary endpoint and data will be used to support biologics license application (BLA) filing for afami-cel next year. Many members of the management came from ALZA Corporation, which was one of the most successful mergers in the above list. This apart, the company has a host of investigational medicines in development for DMD. Medarex bought out GenPharm for $65M. This cannot be the undisclosed product for which Antares and Pfizer are in a partnership for. Price as of January 17, 2023, 4:00 p.m. Oncology and gene therapy were the subjects of acquisitions this year. With focus on discovery, development and commercialization of a strong product portfolio, collaborating with industry-leading partners such as Novartis and Sanofi Genzyme, and an outstanding therapeutics pipeline, Alnylam is one of those biotech gems big pharma companies have on their radar. Total consideration can reflect both cash and equity offered upfront in exchange for the acquired companys shares, but deals in which the upfront payment was not specified, or was less than $50 million, were not included. The Motley Fool recommends Biogen and Gilead Sciences. ATRS. Analysts, on average, predict over 75% upside for Crispr shares. Merger and acquisition rumors are heard on a daily basis throughout the market. There's some people who say that they're disappointed because a company got taken out because they'd rather own the company and profit from the growth of that company individually. The number of done deals dropped to 92 from 101 in 2020 and 111 in 2019. Trading stocks is risky -- always be sure to know and understand your risk tolerance. Hunzinger said: Biotech and smaller medical device deals should continue in the first half of the year, with the second half poised for larger deals driven by a need for scale and an expected settling of the regulatory landscape.. Today, you can download 7 Best Stocks for the Next 30 Days. He utilizes a combination of technical analysis, deep scientific research, and macro views to generate alpha for the team. 11. This biotechnology company, which operates in hemophilia and ultra-orphan disease drug space, has seven approved treatments, a strong pipeline, and steadily growing revenue. Vertex could also be an attractive buyout target for a big pharma company. Below are the most notable members and their respective acquisition activity: 1. 06-01-2023. 12. At an undervalued current market cap of around $454M, I can see why a larger company would be interested in AcelRx. GLOBAL MARKETS-Stocks buoyed by cheery data after BOJ damp squib, Nouriel Roubini: There's a massive disconnect between markets and the Fed, U.S. natgas price slump pushes 'widow maker' toward unusual contango, Germany must speed hydrogen plans this year - gas pipeline group OGE, Ian Bremmer: We're in a hot war with Russia. Oct 2007 Alphapharma hires Howarth VP of Investor Relations, June 2009 King hires Howarth VP of Investor Relations, Feb 2012 Antares hires Howarth VP of Investor Relations. Antares Pharma. You Might Regret That, History Suggests the S&P 500 Could Soar in 2023. Incyte has an attractive pharmaceutical portfolio comprising of Jakafi, a blockbuster drug for rare blood cancer indications, and 3 other marketed drugs, and a well-stocked pipeline. One of those stocks was. Sold ATS Medical, Inc. to Medronics Inc. (MDT): Mr. Nohra served on the Board of Directors of ATS Medical, Inc. Medronics bought out ATS Medical for $370M. M&A deal flow dwindled in 2021, reflecting stricter antitrust laws. Beginning on February 10, 2012, Voce Capital sent a letter to the Obagi Board of Directors criticizing the Board's adoption of a poison pill and demanding immediate action to address the company's corporate governance failures. Someone is "mistaken" here. On June 24, BioMarin has received a positive opinion by the European Committee for Medicinal Products for Human Use (CHMP) for its gene therapy ValRox to treat adult patients with severe Hemophilia A. 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